Anal Cancer in Gay and Bisexual Men

Home » Anal Cancer in Gay and Bisexual Men » Treatment, Prevention

Treatment

Treatment of anal cancer depends on the type of tumor and its stage of development. There are three types of treatment:

• Surgical resection; may be done with laser surgery (usually Stages 0 – II)
• Radiation (usually Stage II and higher)
• Chemotherapy (usually Stage II and higher)

Surgery
A local surgical resection (removal) of the tumor and a small amount of surrounding tissue may suffice in cases of Stage 0 cancer, where the cancer has not metastasized and does not affect the sphincters. In later stages, where cancer has spread, a surgeon may perform an abdominoperineal resection to remove affected tissue, lymph nodes, or sections of or organs in the abdomen. This procedure requires a colostomy, wherein the anus is removed and waste is diverted from the colon through a surgically created opening, through the abdominal wall, and to an external bag for disposal. Abdominoperineal resection is used less frequently because radiation and chemotherapy are effective and do not require a colostomy.

Resection can cause anal stenosis (narrowing) of the anal canal and anus due to scar tissue. Surgery is sometimes required to widen the anus and restore proper function.

Radiation
Radiation, the shrinkage of cancerous tumors with energy waves (e.g., x-rays), is performed with external radiation or internal radioactive implants (radioisotopes). Internal radiation using implants (brachytherapy) involves placing plastic-covered radioactive seeds (pellets) inside the anus, near the cancerous tissue, to shrink tissue. The seeds stay in for the appropriate length of time, perhaps permanently, and require fewer trips to the physician's office. Radiation may be combined with chemotherapy. Radiation causes side effects including loss of control of the sphincter muscle (incontinence), temporary browning of the skin, and fatigue.

Chemotherapy
Chemotherapy involves drug treatment to kill cancer cells. Drugs used to treat anal cancer include 5-fluorouracil (5-FU), mitomycin, and cisplatin, which are administered orally or intravenously. Chemotherapy is a systemic treatment; the drugs enter and travel throughout the body to kill cancer cells wherever they are. All of these drugs (antineoplastic agents) inhibit the normal production and use of deoxyribonucleic acid (DNA), which is needed for cell growth and division. Arrested cell growth results in tumor shrinkage.

Chemotherapy drugs cause acute side effects, including nausea, fatigue, vomiting, fever, diarrhea, and sensitivity to sunlight. Certain drugs are associated with specific side effects. 5-fluorouracil may cause low white blood cell count, ulcers, and visual problems. Mitomycin is associated with bone marrow, kidney, mucous membrane, and pulmonary toxicity, as well as kidney failure. Cisplatin may cause hearing problems, serious disorientation, and anaphylactic (allergic shock) reactions, including respiratory distress and swelling.

Prevention
Avoiding HPV and anogenital warts is the best prevention for anal cancer. Using latex condoms during anal sex significantly reduces the risk for HPV and other STDs, but condoms may not prevent HPV infection. If benign anal lesions are found, routine anal Pap smears and biopsies may detect cancerous cells early enough for successful treatment. Biopsy is recommended every 6 to 12 months for less serious lesions and 3 to 4 months for more serious ones. It is important to consult a physician when a lesion is found anywhere in the anal region.

© 1998-2008 Healthcommunities.com, Inc. All Rights Reserved.

Anal Cancer in Gay and Bisexual Men Resources

	Join Our Anal Cancer Forum Do you have a question, want to share medical advice, or just need to discuss your situation with someone else having a similar experience? The healthchannels forum is a resource for everyone to share and discuss their health and medical needs with others.	Advertising Disclaimer
	Living with...Share your story Do you have a personal health story that you would like to share with others? As a source of free patient education, our goal is to provide our users with trustworthy information and support from others. That's why we've started our "Living with..." sections.
	Our "Living With..." support pages are a place to share experiences about living with a certain condition, disease, disorder, or illness and for loved ones of those dealing with health-related issues. Many people, especially when newly diagnosed, find comfort in knowing that others are having a similar experience. Help others by sharing your story. View stories already submitted.
	Stay Updated Sign up for our newsletter and receive important updates on the medical conditions that are most important to you.
Are you interested in becoming a nurse? Take this test. Advertising Disclaimer To quickly access health information from your website's browser, download Healthcommunities.com's healthchannels toolbar. Advertising Disclaimer